Description:Rabbit polyclonal antibody to Nibrin (Phospho-S343)Immunogen:KLH-conjugated synthetic phosphopeptide corresponding to residues surrounding S343 of human Nibrin protein. The exact sequence is proprietary.Purification:The antibody was purified by immunogen affinity chromatography.Clonality:PolyclonalForm:Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.Dilution:WB (1/500 - 1/1000)Gene Symbol:NBNAlternative Names:NBS; NBS1; P95; Nibrin; Cell cycle regulatory protein p95; Nijmegen breakage syndrome protein 1
Entrez Gene (Human):
4683;
Entrez Gene (Mouse):
27354;
Entrez Gene (Rat):
85482;
SwissProt (Human):
O60934;
SwissProt (Mouse):
Q9R207;
SwissProt (Rat):
Q9JIL9;
Storage/Stability:Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
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Western blot analysis of Nibrin (Phospho-S343) expression in Jurkat (A), LO2 UV-treated (B), Raw264.7 UV-treated (C), PC12 (D) whole cell lysates. (Predicted band size: 84 kD; Observed band size: 95 kD)
The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo
Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition
Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours
Direct Activation of ATM by Resveratrol under Oxidizing Conditions